Top seed, Novak Djokovic showed he is back with his best in the US Open as he ended Kyle Edmund's fine run at to an end with a 6-2 6-1 6-4 fourth-round win.
Djokovic showed no signs of being rusty despite only completing six games in the past two rounds because of injuries to Jiri Vesely and Mikhail Youzhny.
The world number one needed treatment during the third set as the trouble he had with his upper arm in the first round flared up again.
But he came through unscathed to ensure his quest for a 13th Grand Slam title and third this year remains on track.
Edmund enjoyed something of a New York breakthrough, knocking out Richard Gasquet and John Isner in rounds one and three.
But the Briton was outclassed from the start by defending champion Djokovic who play France's Jo-Wilfried Tsonga in the last eight.
Meanwhile in what can be described as the biggest scalp of the night, Rafael Nadal was defeated in the U.S. Open's fourth round by 24th-seeded Frenchman Lucas Pouille in an epic five set thriller on Sunday.
The 4th seeded Spainard was defeated 6-1, 2-6, 6-4, 3-6, 7-6 (6) prolonging the 14-time Grand Slam title winner's quarterfinal drought at major tournaments.
This is the first time since 2004 that Nadal failed to reach a Grand Slam quarter final.
Pouille's upset of Nadal helped put three Frenchmen into the quarterfinals of the American Grand Slam tournament for the first time in 89 years.
The 24th-seeded Pouille joined No. 9 Jo-Wilfried Tsonga and No. 10 Gael Monfils with fourth-round victories Sunday.
Pouille and Monfils will play each other for a berth in the semifinals.
The last time three Frenchmen reached the quarterfinals was back in 1927, when the event was known as the U.S. Championships.
The trio at that time was Jean Borotra, Jacques Brugnon and Rene Lacoste, all members of France's famed "Four Musketeers" group of tennis stars in the 1920s and 1930s.
In other games,Jo-Wilfried Tsonga beat American Jack Sock in four sets to reach the U.S. Open quarterfinals for the second straight year.
After failing to covert one match point in the third-set tiebreaker, the ninth-seeded Tsonga dominated the fourth for the 6-3, 6-3, 6-7 (7), 6-2 victory Sunday.
Sock, the last man from the United States left in the draw, was trying to reach his first major quarterfinal. No American man has made the last eight at the U.S. Open since 2011.
For the women, Second-seed, Angelique Kerber defeated Petra Kvitova in straight sets to reach the U.S. Open quarterfinals for the first time since 2011.
Kerber won 6-3, 7-5 on Sunday in a matchup of left-handers to set up a meeting with last year's runner-up, Roberta Vinci.
The German made her first major semifinal at Flushing Meadows five years ago, but this season came an even bigger breakthrough when she beat Serena Williams for the Australian Open title.
The German could overtake Williams for the No. 1 ranking depending on their U.S. Open results.